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GNF 5837

Catalog #: 4559
3 Citations Datasheet
Catalog # Availability Size / Price Qty
4559/10
4559/50
GNF 5837 | CAS No. 1033769-28-6 | Trk Receptor Inhibitors
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Description: Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Chemical Name: N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GNF 5837 is a potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.

Technical Data

M.Wt:
535.49
Formula:
C28H21F4N5O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1033769-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for GNF 5837

The citations listed below are publications that use Tocris products. Selected citations for GNF 5837 include:

3 Citations: Showing 1 - 3

  1. Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.
    Authors: Chao Et al.
    Elife  2021;10
  2. Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo.
    Authors: Hyung-Jun Et al.
    Br J Pharmacol  2020;177:668-686
  3. Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer.
    Authors: Tsai Et al.
    PLoS One  2017;12:e0178173

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