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GN 44028

Catalog #: 5655 Datasheet
Catalog # Availability Size / Price Qty
5655/10
GN 44028 | CAS No. 1421448-26-1 | HIF Inhibitors
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Description: Potent HIF-1α inhibitor

Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Purity: ≥98%

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Biological Activity

GN 44028 is a potent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.

Technical Data

M.Wt:
305.33
Formula:
C18N15N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1421448-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors.
    Minegishi et al.
    ACS Med.Chem.Lett., 2013;4:297

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