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Glycyl-H 1152 dihydrochloride

Catalog #: 2485
4 Citations Datasheet
Catalog # Availability Size / Price Qty
2485/1
Glycyl-H 1152 dihydrochloride | CAS No. 913844-45-8 | Rho-kinase Inhibitors
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Description: Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

Purity: ≥99%

Product Details
Citations (4)
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Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Technical Data

M.Wt:
449.4
Formula:
C18H24N4O3S.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
913844-45-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Development of specific Rho-kinase inhibitors and their clinical application.
    Tamura et al.
    Biochim.Biophys.Acta, 2005;1754:245

Product Datasheets

Citations for Glycyl-H 1152 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:

4 Citations: Showing 1 - 4

  1. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    PLoS One  2015;85:173
  2. Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys.
    Authors: Lawrence Et al.
    Sci Rep  2015;5:9092
  3. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.
    Authors: Sadaie Et al.
    Mol Biol Cell  2015;26:2971
  4. Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR.
    Authors: Siegel Et al.
    Hum Mol Genet  2010;19:3320

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