GI 530159

Catalog #: 6689 Datasheet

Catalog #	Availability	Size / Price	Qty
6689/10
6689/50

GI 530159 | CAS No. 69563-88-8 | Two-P Potassium Channels Activators

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Description: K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator

Chemical Name: 4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine]

Purity: ≥99%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GI 530159 is a TREK1 and TREK2 channel activator (EC₅₀ = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro.

Technical Data

M.Wt:

518.45

Formula:

C₂₇H₂₀F₆N₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

69563-88-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K_2P) channel opener, reduces rat dorsal root ganglion neuron excitability.
Loucif et al.
Br.J.Pharmacol., 2018;175:2272

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