GI 254023X

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.
   Moss ML, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart PM, Gillispie PA, Stoeck A, Wildeboer D, Bartsch JW, Palmisano R, Zhou P
   J. Biol. Chem., 2007;282(49):35712-21.
2. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons
   RL Sanz, GB Ferraro, MP Girouard, AE Fournier
   Sci Rep, 2017;7(1):7961.
3. Regulation of RAGE ectodomain shedding and its role in cell function
   A Braley, T Kwak, J Jules, E Harja, R Landgraf, BI Hudson
   J Biol Chem, 2016;0(0):.
4. TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant
   P Thornton, J Sevalle, MJ Deery, G Fraser, Y Zhou, S Ståhl, EH Franssen, RB Dodd, S Qamar, B Gomez Pere, LS Nicol, S Eketjäll, J Revell, C Jones, A Billinton, PH St George-, I Chessell, DC Crowther
   EMBO Mol Med, 2017;0(0):.
5. Protective role of cellular prion protein against TNF?-mediated inflammation through TACE ?-secretase
   J Ezpeleta, F Boudet-Dev, M Pietri, A Baudry, V Baudouin, A Alleaume-B, N Dagoneau, O Kellermann, JM Launay, B Schneider
   Sci Rep, 2017;7(1):7671.
6. CD44 Interacts with HIF-2? to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells
   E Johansson, ES Grassi, V Pantazopou, B Tong, D Lindgren, TJ Berg, EJ Pietras, H Axelson, A Pietras
   Cell Rep, 2017;20(7):1641-1653.
7. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice.
   Inoshima et al.
   Nat.Med., 2011;17:1310
8. Metalloprotease inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.
   Ludwig et al.
   Comb.Chem.High Throughput Screen., 2005;8:161
9. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediates cell-cell adhesion.
   Hundhausen et al.
   Blood, 2003;102:1186

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