GeA-69
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Description: Selective allosteric PARP14 inhibitor
Chemical Name: N-[2-(9H-Carbazol-1-yl)phenyl]acetamide
Purity: ≥98%
Biological Activity
GeA-69 is a selective allosteric inhibitor of poly (ADP-ribose) polymerase 14 (PARP14) macrodomain 2 (MD2) (IC50 = 720 nM, Kd = 860 nM). It inhibits adenosine diphosphate ribose (ADPR) binding to the macrodomain 2 of PARP14 and prevents PARP14 MD2 localization to DNA damage sites in intact cells. GeA-69 is highly cell permeable.Technical Data
M.Wt:
300.35
Formula:
C20H16N2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2143475-98-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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