Gap 27
Purity: ≥95%
Biological Activity
Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries.
Chaytor et al.
J.Physiol., 1998;508:561 -
Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts.
Ko et al.
Am.J.Physiol.Cell Physiol., 2000;279:C147 -
Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor.
Richards et al.
Br.J.Pharmacol., 2001;134:1
Product Datasheets
Citations for Gap 27
The citations listed below are publications that use Tocris products. Selected citations for Gap 27 include:
2 Citations: Showing 1 - 2
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Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
Authors: Dosch Et al.
Elife 2019;8
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Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Authors: Westphalen Et al.
Nature 2014;506:503
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