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G6PDi 1

Catalog #: 7561 Datasheet
Catalog # Availability Size / Price Qty
7561/10
G6PDi 1 | CAS No. 2457232-14-1 | G6PD
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Description: Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor

Chemical Name: 4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile

Purity: ≥98%

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Biological Activity

G6PDi 1 is a potent, reversible, nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD) (IC50 = 70 nM. The compound dose-dependently and reversibly decreases 6-phosphogluconolactone (6-PG) levels in HCT116 and HepG2 cell lines in vitro. In activated T cells, G6PDi-1 inhibits flux through the pentose phosphate pathway and decreases NADPH generation. It also inhibits production of cytokines by activated T cells and oxidative burst in neutrophils.

Technical Data

M.Wt:
284.34
Formula:
C14H12N4OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2457232-14-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Princeton University

Product Datasheets

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