G-36

Catalog #: 4759
3 Citations Datasheet

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G-36 | CAS No. 1392487-51-2 | Estrogen and Related Receptor Antagonists

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Description: Selective GPER antagonist

Chemical Name: (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

Purity: ≥99%

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Product Details

Citations (3)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

G-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC₅₀ = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Technical Data

M.Wt:

412.33

Formula:

C₂₂H₂₂BrNO₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at -20°C

CAS No:

1392487-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The G-protein-coupled estrogen receptor GPER in health and disease.
Prossnitz and Barton
Nat.Rev.Endocrinol., 2011;7:715
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.
Dennis et al.
J.Steroid Biochem.Mol.Biol., 2011;127:358

Product Datasheets

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Citations for G-36

The citations listed below are publications that use Tocris products. Selected citations for G-36 include:

3 Citations: Showing 1 - 3

Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats.
Authors: Jing Et al.
Biology (Basel) 2023;12
G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
Authors: Bin Et al.
J Neuroinflammation 2020;17:45
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Authors: Meseke Et al.
Eneuro 2018;5

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