FzM1.8
Chemical Name: 3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
Purity: ≥98%
Biological Activity
FzM1.8 is a frizzled 4 allosteric agonist (pEC50 = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist.
Riccio et al.
Biochemistry, 2018;57:839
Product Datasheets
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