FX 1
Chemical Name: (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
Purity: ≥98%
Biological Activity
FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
Cardenas et al.
J.Clin.Invest., 2016;126:3351 -
The expanding role of the BCL6 oncoprotein as a cancer therapeutic target.
Cardenas et al.
Clin.Cancer Res., 2017;23:885
Product Datasheets
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