FPS ZM1
Chemical Name: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
Purity: ≥99%
Biological Activity
FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A multimodal RAGE-specific inhibitor reduces amyloid �-mediated brain disorder in a mouse model of Alzheimer disease.
Deane et al.
J.Clin.Invest., 2012;122:1377 -
Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-� Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus.
Hong et al.
Neurochem.Res., 2016;41:1192
Product Datasheets
Citations for FPS ZM1
The citations listed below are publications that use Tocris products. Selected citations for FPS ZM1 include:
3 Citations: Showing 1 - 3
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Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma.
Authors: Hui Et al.
Exp Ther Med 2021;21:470
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S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response.
Authors: Venkat Et al.
Front Cell Infect Microbiol 2021;11:739874
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Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Authors: Uderhardt Et al.
Cell 2019;177:541
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