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Flupenthixol dihydrochloride

Catalog #: 4057
6 Citations Datasheet
Catalog # Availability Size / Price Qty
4057/50
Flupenthixol dihydrochloride | CAS No. 2413-38-9 | Non-selective Dopamine Receptor Antagonists
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Description: Dopamine antagonist
Alternative Names: Flupentixol

Chemical Name: 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride

Purity: ≥99%

Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Flupenthixol dihydrochloride is an antipsychotic drug. Exhibits antagonistic activity at dopamine D1-5 receptors. Used in schizophrenia treatment.

This compound is a mixture of E/Z isomers (ratio: 60:40).

Technical Data

M.Wt:
507.44
Formula:
C23H25F3N2OS.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
2413-38-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • This compound is a mixture of E/Z isomers (ratio: 60:40)

Background References

  1. Pharmacological properties of new antipsychotic agents: Use of animal models.
    Peuch et al.
    Neuropharmacology, 1981;20:1279

Product Datasheets

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Citations for Flupenthixol dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Flupenthixol dihydrochloride include:

6 Citations: Showing 1 - 6

  1. Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.
    Authors: Eero Et al.
    Front Pharmacol  2022;12:755600
  2. Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
    Authors: Clive R Et al.
    Cell  2021;184:1299-1313.e19
  3. A critical role for the Drosophila DA D1-like receptor Dop1R2 at the onset of metamorphosis.
    Authors: Regna Et al.
    PLoS One  2016;16:15
  4. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
    Authors: FitzGerald Et al.
    PLoS One  2014;9:e98891
  5. Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity.
    Authors: Nicole F Et al.
    Biol Psychiatry  2013;73:464-71
  6. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol  2012;167:1480

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