Ferrostatin 1

Biological Activity

Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC₅₀ = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Ferroptosis: an iron-dependent form of nonapoptotic cell death.
   Dixon et al.
   Cell, 2012;149:1060
2. FerroSTAT inhibit oxidative lipid damage and cell death in diverse disease models.
   Skouta et al.
   J.Am.Chem.Soc., 2014;136:4551
3. Iron-dependent cell death of hepatocellular carcinoma cells exposed to sora.
   Louandre et al.
   Int.J.Cancer, 2013;133:1732

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