Fatostatin A
Chemical Name: 4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
Purity: ≥97%
Biological Activity
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis
PLoS Pathog, 2016;12(12):e1006088. -
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
Kamisuki et al.
Chem.Biol., 2009;16:882 -
Identification of bioactive molecules by adipogenesis profiling of organic compounds.
Choi et al.
J.Biol.Chem., 2003;278:7320
Product Datasheets
Citations for Fatostatin A
The citations listed below are publications that use Tocris products. Selected citations for Fatostatin A include:
7 Citations: Showing 1 - 7
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Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production.
Authors: Keith S Et al.
Sci Rep 2021;11:16347
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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Authors: Almut Et al.
Cell Rep 2020;31:107806
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Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.
Authors: Xuejun Et al.
Proc Natl Acad Sci U S A 2020;117:31189-31197
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The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Authors: Tania Et al.
Immunity 2019;51:241-257.e9
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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs.
Authors: Csaba Et al.
Cell Stem Cell 2019;25:120-136.e10
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Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.
Authors: Roche Et al.
J Cell Biol 2018;217:3560
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Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.
Authors: Uma Kant Et al.
J Biol Chem 2015;290:9571-87
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