Evans Blue tetrasodium salt
Chemical Name: 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt
Purity: ≥90%
Biological Activity
Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist. Also a non-permeating dye, stains damaged plasma membrane and enters in the cytoplasm and nucleus, used for checking cell viability.Optical Data for Evans Blue tetrasodium salt
| Emission Color | Red |
|---|---|
| λem | 680 nm |
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Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction
R Nakazato, K Kawabe, D Yamada, S Ikeno, M Mieda, S Shimba, E Hinoi, Y Yoneda, T Takarada
J. Neurosci., 2017;0(0):. -
Evans blue antagonizes both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates desensitization.
Price and Raymond
Mol. Pharmacol., 1996;50:1665 -
Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter.
Roseth et al.
J.Neurochem., 1995;65:96 -
P2-purinoceptor antagonists:II blockade of P2-purinoceptor subtypes and ecto-nucleotidase by compounds related to Evans blue and trypan blue.
Wittenburg et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1996;354:491 -
Differential modulation of AMPA receptor mediated currents by Evans Blue in postnatal rat hippocampal neurones.
Schurmann et al.
Br.J.Pharmacol., 1997;121:237
Product Datasheets
Citations for Evans Blue tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for Evans Blue tetrasodium salt include:
2 Citations: Showing 1 - 2
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Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Authors: Uderhardt Et al.
Cell 2019;177:541
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Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors.
Authors: Gao Et al.
Virulence 2018;9:1601
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