Eticlopride hydrochloride
Chemical Name: 3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride
Purity: ≥99%
Biological Activity
Eticlopride hydrochloride is a selective dopamine D2/D3 receptor antagonist (Ki values are 0.50 and 0.16 nM respectively). Antipsychotic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning.
Neuron, 2013;77(2):335-45. -
Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for DA-D2 receptors in the rat brain.
Hall et al.
Eur.J.Pharmacol., 1985;111:191 -
Involvement of DA receptors in the antipsychotic profile of (-) eticlopride.
Giuliani and Ferrari
Physiol.Behav., 1997;61:563 -
The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys.
Claytor et al.
Pharmacol.Biochem.Behav., 2006;83:456
Product Datasheets
Citations for Eticlopride hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Eticlopride hydrochloride include:
7 Citations: Showing 1 - 7
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Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Authors: Dorst Et al.
Nat Commun 2020;11:5113
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A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila.
Authors: Cassar Et al.
J Ginseng Res 2015;24:197
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Effects of DA D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
Authors: Jensen
PLoS One 2015;10:e0146154
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DA in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.
Authors: Kramar Et al.
Int J Neuropsychopharmacol 2014;39:1645
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Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats.
Authors: Zhao Et al.
Neuropsychopharmacology 2014;38:256
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Functional integration of grafted neural stem cell-derived DArgic neurons monitored by optogenetics in an in vitro Parkinson model.
Authors: Tønnesen Et al.
PLoS One 2011;6:e17560
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DArgic regulation of sleep and cataplexy in a murine model of narcolepsy.
Authors: Burgess Et al.
Sleep 2010;33:1295
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