ESI 09
Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
Purity: ≥98%
Biological Activity
ESI 09 is an EPAC inhibitor. Inhibits EPAC-mediated insulin release from pancreatic β cells. Selective for EPAC over PKA. ESI 09 decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport
A Guichard, P Jain, M Moayeri, R Schwartz, S Chin, L Zhu, B Cruz-Moren, JZ Liu, B Aguilar, A Hollands, SH Leppla, V Nizet, E Bier
PLoS Pathog., 2017;13(9):e1006603. -
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
Almahariq et al.
Mol.Pharmacol., 2013;83:122
Product Datasheets
Citations for ESI 09
The citations listed below are publications that use Tocris products. Selected citations for ESI 09 include:
13 Citations: Showing 1 - 10
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Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia.
Authors: Derek C Et al.
J Neurosci 2021;41:2883-2898
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β2-adrenergic receptor regulates ER-mitochondria contacts.
Authors: Ginam Et al.
Sci Rep 2021;11:21477
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Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
Authors: Chris Et al.
Elife 2020;9
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Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Authors: Alyson E Et al.
Cell Chem Biol 2020;27:657-667.e6
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Phospho-substrate profiling of Epac-dependent protein kinase C activity.
Authors: Diana J Et al.
Mol Cell Biochem 2019;456:167-178
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Elevated glucose concentration in culture media decreases membrane trafficking of SGLT2 in LLC-PK1 cells via a cAMP/PKA-dependent pathway.
Authors: Siddharth Et al.
Am J Physiol Cell Physiol 2019;316:C913-C924
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Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.
Authors: Caglar Et al.
J Immunol 2019;203:3247-3255
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Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
Authors: Jeremy F Et al.
Cell 2019;179:1289-1305.e21
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The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability.
Authors: Cheng-Mao Et al.
J Biol Chem 2018;293:717-730
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Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Authors: Perkins Et al.
Nat.Immunol. 2018;19:1309
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Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells.
Authors: Drelich Et al.
Viruses 2018;10
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Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.
Authors: Guichard Et al.
PLoS Pathog 2017;13:e1006603
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A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
Authors: Wang Et al.
EMBO Mol Med 2015;11:2057
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