ERB 041
Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Purity: ≥98%
Biological Activity
ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen
GL Owens, KM Lawrence, TR Jackson, EJ Crosbie, BS Sayan, HC Kitchener, PA Townsend
Cancer Med, 2017;0(0):. -
Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands.
Malamas et al.
J.Med.Chem., 2004;47:5021 -
Evaluaton of an estrogen receptor-β agonist in animal models of human disease.
Harris et al.
Endocrinology, 2003;144:4241 -
Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes.
Cvoro et al.
J.Immunol., 2008;180:630
Product Datasheets
Citations for ERB 041
The citations listed below are publications that use Tocris products. Selected citations for ERB 041 include:
2 Citations: Showing 1 - 2
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Estrogen Receptor β Contributes to Both Hypertension and Hypothalamic Plasticity in a Mouse Model of Peri-Menopause.
Authors: Gang Et al.
J Neurosci 2021;41:5190-5205
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GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
Authors: Cortes Et al.
EMBO Rep. 2018;:e46556
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