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EN6

Catalog #: 7474 Datasheet
Catalog # Availability Size / Price Qty
7474/10
7474/50
EN6 | CAS No. 1808714-73-9 | H+-ATPase Inhibitors
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Description: H+-ATPase activator; activates autophagy; inactivates mTORC1 signaling

Chemical Name: N-[4-Fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide

Purity: ≥98%

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Biological Activity

EN6 is an activator of lysosomal vacuolar H+ ATPase (v-ATPase). EN6 covalently binds to the catalytic subunit of v-ATPase leading to increased acidification of lysosomes, inactivation of mTORC1 signaling and activation of autophagy in vivo. EN6 triggers entosis and promotes clearance of TDP43 protein aggregates in vitro.

Technical Data

M.Wt:
368.34
Formula:
C19H14F2N4O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1808714-73-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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