Ellipticine
Chemical Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Purity: ≥97%
Biological Activity
Ellipticine is a naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
Tewey et al.
J.Biol.Chem., 1984;259:9182 -
Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism.
Ohashi et al.
Jpn.J.Cancer Res., 1995;86:819
Product Datasheets
Citations for Ellipticine
The citations listed below are publications that use Tocris products. Selected citations for Ellipticine include:
2 Citations: Showing 1 - 2
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IDA is a broad-spectrum enterovirus replication inhibitor that selectively targets the virus internal ribosomal entry site.
Authors: Hou Et al.
J Gen Virol 2016;97:1122
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Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.
Authors: Kishikawa Et al.
Oncotarget 2015;6:8339
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