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EG 00229 trifluoroacetate

Catalog #: 6986
3 Citations Datasheet
Catalog # Availability Size / Price Qty
6986/10
EG 00229 trifluoroacetate | CAS No. 1210945-69-9 | VEGF Receptor Inhibitors
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Description: Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

Chemical Name: N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

Technical Data

M.Wt:
611.59
Formula:
C17H19N7O5S3.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1210945-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for EG 00229 trifluoroacetate

The citations listed below are publications that use Tocris products. Selected citations for EG 00229 trifluoroacetate include:

3 Citations: Showing 1 - 3

  1. SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
    Authors: Rajesh Et al.
    Pain  2021;162:243-252
  2. Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry.
    Authors: Curtis A Et al.
    ACS Chem Neurosci  2021;12:1299-1312
  3. Neuropilin-1 is a host factor for SARS-CoV-2 infection.
    Authors: Daly Et al.
    Science  2020;370:861

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