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EED 226

Catalog #: 7762 Datasheet
Catalog # Availability Size / Price Qty
7762/50
7762/10
EED 226 | CAS No. 2083627-02-3 | EED
1 Image
Description: Potent and selective EED inhibitor

Chemical Name: N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine

Purity: ≥98%

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Biological Activity

EED 226 is a potent (IC50 = 23.4 nM) and selective EED inhibitor. It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED. The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes. In vitro, EED 226 regulates histone H3K27 methylation and PRC2 target gene expression. In vivo, it induces tumor regression in a mouse xenograft model. EED 226 is orally bioavailable.

Technical Data

M.Wt:
369.4
Formula:
C17H15N5O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2083627-02-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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