Edaglitazone
Chemical Name: 5-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione
Purity: ≥98%
Biological Activity
Edaglitazone is a potent and selective PPARγ agonist (EC50 values are 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively. Enhances insulin sensitivity in obese, but not lean, rats. Antidiabetic and orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism.
Fürnsinn et al.
Br. J. Pharmacol., 1999;128:1141 -
Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors.
Dietz et al.
ChemMedChem, 2012;7:1101
Product Datasheets
Citation for Edaglitazone
The citations listed below are publications that use Tocris products. Selected citations for Edaglitazone include:
1 Citation: Showing 1 - 1
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An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor.
Authors: Hui Et al.
Cell Death Dis 2022;13:356
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