Echistatin, α1 isoform

Catalog # Availability Size / Price Qty
3202/100U
Echistatin, α1 isoform
1 Image
Description: αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor

Purity: ≥95%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Echistatin, α1 isoform is a potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro.

Technical Data

M.Wt:
5417.1
Formula:
C217H341N71O74S9
Sequence:
ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT

(Modifications: Disulfide bridges: 2-11, 7-32, 8-37, 20-39)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
154303-05-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Echistatin, α1 isoform

The citations listed below are publications that use Tocris products. Selected citations for Echistatin, α1 isoform include:

2 Citations: Showing 1 - 2

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