Ebselen

Biological Activity

Ebselen is a glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits ferroptosis. Also inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H⁺/K⁺-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B₁. Antioxidant and anti-inflammatory. Selectively inhibits G_q protein signaling and enhances differentiation of brown adipocytes. Inhibits SARS-CoV-2 M^pro in vitro (IC₅₀ = 0.67 μM in FRET assay)

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Molecular actions of ebselen--an antiinflammatory antioxidant.
   Schewe
   Gen.Pharmacol., 1995;26:1153
2. Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats.
   Yang et al.
   Carcinogenesis, 2000;21:2237
3. Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound.
   Fujisawa and Kadoma
   Anticancer Res., 2005;25:3989
4. Ferroptosis: process and function.
   Xie et al.
   Cell.Death.Differ, 2016;23:369
5. Cell-permeable high-affinity tracers for G_q proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors.
   Kuschak et al.
   Br.J.Pharmacol., 2019;
6. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors.
   Jin et al.
   Nature., 2020;582:289

Product Datasheets