E 2012
Chemical Name: (3E)-1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-2-piperidone
Purity: ≥98%
Biological Activity
E 2012 is a γ-secretase modulator. Lowers Aβ40 and Aβ42 levels and increases Aβ37 levels, in vitro and in vivo. Displays no effect on γ-secretase processing of Notch, EphA4 and EphB2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.
Borgegard et al.
J.Biol.Chem., 2012;287:15 -
Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.
Portelius et al.
J.Alzheimers Dis., 2010;21:1005
Product Datasheets
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