Dynarrestin
Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
Purity: ≥98%
Biological Activity
Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Dynarrestin, a novel inhibitor or cytoplasmic dynein.
Höing et al.
Cell Chem.Biol., 2018;25:357
Product Datasheets
Citations for Dynarrestin
The citations listed below are publications that use Tocris products. Selected citations for Dynarrestin include:
3 Citations: Showing 1 - 3
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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix.
Authors: Sandra L Et al.
iScience 2023;26:105965
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Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing.
Authors: Jian Et al.
ACS Nano 2021;15:17528-17548
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Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles.
Authors: Charles E Et al.
J Virol 2019;93
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