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DX3-213B

Catalog #: 8070 Datasheet
Catalog # Availability Size / Price Qty
8070/10
DX3-213B | CAS No. 2749555-66-4 | Oxidative Phosphorylation Inhibitors
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Description: Potent NDUFS7 antagonist

Chemical Name: (4,4-Difluoro-1-piperidinyl)[(3R)-1-[[4-[(1-methylethyl)sulfonyl]phenyl]sulfonyl]-3-piperidinyl]methanone

Purity: ≥97%

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Biological Activity

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I (also known as NDUFS7) antagonist (IC50 = 3.6 nM). DX3-213B impairs ATP generation (IC50 = 11 nM) and inhibits the proliferation of MIA PaCa-2 cells (IC50 = 9 nM) in galactose-containing media. In vivo, DX3-213B significantly delays tumor growth in a syngeneic mouse model of pancreatic cancer. DX3-213B is orally bioavailable.

Technical Data

M.Wt:
478.57
Formula:
C20H28F2N2O5S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
2749555-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Michigan

Product Datasheets

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