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dTAGV-1 hydrochloride

Catalog #: 7374 Datasheet
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dTAGV-1 hydrochloride | CAS No. 2624313-16-0 | TAG Degradation Platforms
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Description: Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride

Purity: ≥98%

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Biological Activity

dTAGV-1 hydrochloride is a hydrochloride salt of dTAGV-1 (Cat. No. 6914). Suitable for use in vivo. Following ip administration of 10 mg/kg in mice: T½ = 4.43 h; Cmax = 2123 ng mL-1; AUCinf = 18517 hr*ng mL-1 and CL = 9.05 mL min-1 kg-1

Negative control dTAGV-1-NEG (Cat. No. 6915) also available.

Important: It is recommended that DMSO stock solutions of this compound are made and used on the same day and are not subjected to freeze/thaw.

Technical Data

M.Wt:
1284.01
Formula:
C68H90N6O14S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2624313-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules.
    Nabet et al.
    Nat.Commun., 2020;11:4687

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