dTAG-Biotin
Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-((2,16-dioxo-20-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosyl)oxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
Biological Activity
dTAG-Biotin is an affinity probe for mutant FKBP12F36V proteins. Comprises the ligand ortho-AP1867, selective for F36V single-point mutated FKBP12, joined by a PEG3 linker to biotin. It can be used for chemical biology studies such as proteomics, enrichment studies, dimerization experiments, and assay validation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The dTAG system for immediate and target-specific protein degradation.
Nabet et al.
Nat.Chem.Biol., 2018;14:431
Product Datasheets
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