DSR 6434
Chemical Name: 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
Purity: ≥98%
Biological Activity
DSR 6434 is a potent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models.
Adlard et al.
Int.J.Cancer, 2014;135:820 -
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
Nakamura et al.
Bioorg.Med.Chem.Lett., 2013;23:669 -
In vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer
AH Negussie, AS Mikhail, JW Owen, N Hong, CJ Carlson, Y Tang, KP Carrow, M Mauda-Hava, AL Lewis, JW Karanian, WF Pritchard, BJ Wood
Scientific Reports, 2022;12(1):21886.
Product Datasheets
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