DQP 1105
Chemical Name: 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid
Purity: ≥97%
Biological Activity
DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Mechanism for noncompetitive inhibition by novel GluN2C/D N-MthD.-aspartate receptor subunit-selective modulators.
Acker et al.
Mol.Pharmacol., 2011;80:782
Product Datasheets
Citations for DQP 1105
The citations listed below are publications that use Tocris products. Selected citations for DQP 1105 include:
2 Citations: Showing 1 - 2
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Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Authors: Brancaccio Et al.
Neuron 2017;93:1420
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Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
Authors: Lozovaya Et al.
Nat Commun 2014;5:4563
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