DPTIP

Catalog #: 6903 Datasheet

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DPTIP | CAS No. 351353-48-5 | Hydrolase Inhibitors

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Description: Potent and selective N-SMase2 inhibitor; brain penetrant

Chemical Name: 2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol

Purity: ≥98%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC₅₀ = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.

Technical Data

M.Wt:

378.45

Formula:

C₂₁H₁₈N₂O₃S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

351353-48-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
Rojas et al.
Sci.Rep., 2018;8:17715

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