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Dopamine hydrochloride

Catalog #: 3548
21 Citations Datasheet
Catalog # Availability Size / Price Qty
3548/50
Dopamine hydrochloride | CAS No. 62-31-7 | Trace Amine 1 (TA1) Receptor Agonists
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Description: Endogenous agonist at dopamine D1-5 receptors

Chemical Name: 3,4-Dihydroxyphenethylamine hydrochloride

Purity: ≥99%

Product Details
Citations (21)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Dopamine hydrochloride is an endogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis.

Technical Data

M.Wt:
189.64
Formula:
C8H11NO2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
62-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel insights into DA receptor pharmacology.
    Rivonello et al.
    Eur.J.Endocrinol., 2007;156:S13
  2. Role of DA in the motivational and cognitive control of behavior.
    Cools
    Neuroscientist, 2008;14:381
  3. Prolactin and DA: what is the connection? A review article.
    Fitzgerald and Dinan
    J.Psychopharmacol., 2008;22:S12

Product Datasheets

Citations for Dopamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Dopamine hydrochloride include:

21 Citations: Showing 1 - 10

  1. Autoregulation of GPCR signalling through the third intracellular loop.
    Authors: Ning Et al.
    Nature  2023;615:734-741
  2. Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors.
    Authors: Kira E Et al.
    Cell Rep  2022;40:111426
  3. Agonist and antagonist TRUPATH assays for G protein-coupled receptors.
    Authors: Bryan L Et al.
    STAR Protoc  2022;3:101259
  4. History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning.
    Authors: Mark L Et al.
    Cell Rep  2022;38:110297
  5. Bingeing on High-Fat Food Enhances Evoked Dopamine Release and Reduces Dopamine Uptake in the Nucleus Accumbens.
    Authors: Sara R Et al.
    Obesity (Silver Spring)  2021;29:721-730
  6. Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird.
    Authors: Mou Et al.
    Nat Commun  2021;12:2617
  7. New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling.
    Authors: Stefan Et al.
    Sci Rep  2021;11:8288
  8. Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray.
    Authors: Spencer T Et al.
    Elife  2020;9
  9. Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism.
    Authors: Fang Et al.
    Oncotarget  2020;11:4224-4242
  10. Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons.
    Authors: Mark D Et al.
    Neuron  2020;106:277-290.e6
  11. Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.
    Authors: Thomas C Et al.
    Cell  2019;179:498-513.e22
  12. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.  2017;16(6):1323
  13. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  14. Retroactive modulation of spike timing-dependent plasticity by DA.
    Authors: Brzosko Et al.
    Elife  2015;4
  15. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  16. Palatability Can Drive Feeding Independent of AgRP Neurons.
    Authors: Bénédicte Et al.
    Cell Metab  2015;22:646-57
  17. Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
    Authors: Zheng Et al.
    Physiol Res  2014;306:R138
  18. Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians.
    Authors: Zhang Et al.
    Physiol Behav  2013;112-113:8
  19. Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs.
    Authors: Kucka Et al.
    World J Gastroenterol  2012;61:267
  20. Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels.
    Authors: Martin Et al.
    Learn Mem  2012;19:294-9
  21. DA-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF.
    Authors: O'Keeffe Et al.
    Proc Natl Acad Sci U S A  2009;106:8754

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