DMOG

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.
   Jackson CS, Durandt C, Janse van Rensburg I et al.
   Stem Cell Res.
2. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
   RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari, AA Rahman, J Pawling, W Zhang, A Sinha, CM Rose, M Isasa, S Zhang, R Wu, C Virtanen, T Hitomi, T Habu, SS Sidhu, A Koizumi, SE Wilkins, T Kislinger, SP Gygi, CJ Schofield, JW Dennis, BG Wouters, BG Neel
   Nat. Cell Biol, 2016;18(7):803-13.
3. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
   
   Nat Cell Biol, 2016;18(7):803-13.
4. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
   Robert S Banh
   Nat Cell Biol, 2016;18(7):803-13.
5. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O₂-regulated prolyl hydroxylation.
   Jaakkola et al.
   Science, 2001;292:468
6. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne
   Lomb et al.
   Mol.Pharmacol., 2009;75:1198
7. Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury.
   Barnucz et al.
   J.Pharmacol.Exp.Ther., 2013;345:25
8. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.
   Ayrapetov et al.
   PLoS One, 2011;6:e26064

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