Diphenyleneiodonium chloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Flavin-containing enzymes as a source of reactive oxygen species in HEMA-induced apoptosis
   H Schweikl, M Gallorini, M Forstner, C Petzel, C Bolay, KA Hiller, A Cataldi, S Krifka, W Buchalla
   Dent Mater, 2017;0(0):.
3. Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.
   Tew
   Biochemistry, 1993;32:10209
4. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.
   Ye et al.
   J.Pharmacol.Exp.Ther., 2014;349:437
5. Inhibitory actions of diphenyleneiodonium dependent vasodilations in vitro and in vivo.
   Wang et al.
   Br.J.Pharmacol., 1993;110:1232
6. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.
   Stuehr et al.
   FASEB J., 1991;5:98
7. Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.
   Yea et al.
   Biochem.J., 1990;265:95

Product Datasheets