DIDS
Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
Purity: ≥95%
Biological Activity
DIDS is a ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids.
Riquelme and Parra et al.
Am.J.Obstet.Gynecol., 1999;180:469 -
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Ishida et al.
Nucleic Acids Res., 2009;37:3367 -
New light on the "old" chloride channel blocker DIDS.
Wulff
ACS Chem.Biol., 2008;3:399 -
Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.
Zhang et al.
Mol.Pharmacol., 2012;81:689
Product Datasheets
Citations for DIDS
The citations listed below are publications that use Tocris products. Selected citations for DIDS include:
10 Citations: Showing 1 - 10
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Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter.
Authors: Matthew Et al.
J Physiol 2021;599:3195-3220
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Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel.
Authors: Xing-Zhen Et al.
iScience 2021;24:103395
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Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
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Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression.
Authors: Myung-Jin Et al.
Cells 2020;9
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Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts.
Authors: Georg Et al.
Cell Death Dis 2020;11:714
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Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255-257 and regulated by mTOR.
Authors: Bernhard Et al.
Glia 2019;67:2264-2278
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The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.
Authors: Roebber Et al.
J Neurosci 2019;39:6224
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TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.
Authors: Koichi Et al.
Neuron 2019;104:960-971.e7
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SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
Authors: Cao Et al.
BMB Rep 2014;289:23189
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Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
J Biol Chem 2013;4:e969
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