DEL 22379
Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
Purity: ≥98%
Biological Activity
DEL 22379 is an ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes.
Herrero et al.
Cancer Cell, 2015;28:170 -
Targeting RAS-mutant cancers: is ERK the key?
Ryan et al.
Trends Cancer, 2015;1:183
Product Datasheets
Citation for DEL 22379
The citations listed below are publications that use Tocris products. Selected citations for DEL 22379 include:
1 Citation: Showing 1 - 1
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The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER.
Authors: Saranya Santhosh Et al.
Cell 2019;179:1306-1318.e18
FAQs
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