Decitabine
Chemical Name: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Purity: ≥99%
Biological Activity
Decitabine is a cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.For more information about how Decitabine may be used, see our protocol:
Highly Efficient Generation of CiPSCs from MEFsTechnical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.
Park H, Choi Y, Kim J, Chun H, Im I, Yoon S, Han Y, Song C, Kim H
PLoS ONE, 2015;10(7):e0132992. -
Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines.
Bender et al.
Cancer Res., 1998;58:95 -
Pharmacology of 5-aza-2'-deoxycytidine (decitabine).
Momparler
Semin.Hematol., 2005;42:S9 -
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase.
Jackson-Grusby et al.
Proc.Natl.Acad.Sci.USA, 1997;94:4681
Product Datasheets
Citations for Decitabine
The citations listed below are publications that use Tocris products. Selected citations for Decitabine include:
6 Citations: Showing 1 - 6
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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
Nature 2016;539:390
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Evaluation of azacit. and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer.
Authors: Vendetti Et al.
Genes Dev 2015;6:56
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Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.
Authors: Gu Et al.
J Biol Chem 2014;289:14881
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Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways.
Authors: Wang Et al.
PLoS One 2012;7:e39446
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Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Authors: Trowbridge Et al.
BMC Cancer 2012;26:344
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Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
Authors: Perera Et al.
PLoS One 2009;4:e4488
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