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DCA

Catalog #: 2755 Datasheet
Catalog # Availability Size / Price Qty
2755/100
DCA | CAS No. 2156-56-1 | Other Kinase Inhibitors
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Description: Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor

Chemical Name: Sodium dichloroacetate

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Biological Activity

DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.

Technical Data

M.Wt:
150.92
Formula:
C2HCl2NaO2
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at RT
CAS No:
2156-56-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.
    Bowker-kinley et al.
    Biochem.J., 1998;329:191
  2. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
    Bonnet et al.
    Cancer Cell, 2007;11:37
  3. The pharmacology of dichloroacetate.
    Stacpoole
    Metabolism Clin.Exp., 1989;38:1124

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