Dantrolene, sodium salt
Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Purity: ≥98%
Biological Activity
Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.
Hotchkiss and Karl
Proc.Natl.Acad.Sci.U.S.A., 1994;91:3039 -
Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus.
O'Mara et al.
Neuroscience, 1995;68:621 -
Dantrolene inhibition of ryanodine receptor Ca2+ release channels.
Zhao et al.
J.Biol.Chem., 2001;276:13810
Product Datasheets
Citations for Dantrolene, sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:
9 Citations: Showing 1 - 9
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High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
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Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
Neuron 2017;93:587
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Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
Authors: Florea Et al.
Oncotarget 2017;8:22876
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Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
Authors: Efthymiou Et al.
Int J Mol Sci 2015;4:230
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Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
Authors: Lin Et al.
FEMS Immunol Med Microbiol 2015;16:5555
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Role of Na+/Ca2+ exchanger in Ca2+ homeostasis in rat suprachiasmatic nucleus neurons.
Authors: Wang Et al.
J Neurophysiol 2015;113:2114
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Mobilization of calcium from intracellular stores facilitates somatodendritic DA release.
Authors: Patel Et al.
J Neurosci 2009;29:6568
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Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo.
Authors: Drdla and Sandkühler
Mol Pain 2008;4:18
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Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
Authors: Wieland Et al.
J Pharmacol Exp Ther 2006;47:296
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