D-Amphetamine sulfate
Chemical Name: (+)-α-Methylphenethylamine hemisulfate salt
Purity: ≥99%
Biological Activity
D-Amphetamine sulfate is a cNS stimulant. Targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin. Also α7 nAChR antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effects of withdrawal from an escalating dose schedule of d-Amphetamine on sexual behavior in the male rat.
Barr et al.
Pharmacol.Biochem.Behav., 1999;64:597 -
The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-Amphetamine motor behaviors in rats.
Cartmell et al.
J.Pharmacol.Exp.Ther., 1999;291:161 -
Balance between DA and serotonin release modulates behavioral effects of Amphetamine-type drugs.
Rothman and Baumann
Ann.N.Y.Acad.Sci., 2006;1074:245 -
Amphetamine enantiomers inhibit homomeric a7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans.
Garton et al.
Neuropharmacology, 2018;
Product Datasheets
Citations for D-Amphetamine sulfate
The citations listed below are publications that use Tocris products. Selected citations for D-Amphetamine sulfate include:
8 Citations: Showing 1 - 8
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Amphetamine enantiomers inhibit homomeric α7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans.
Authors: Garton Et al.
Neuropharmacology 2019;144:172
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Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
Authors: Sánchez-Blázquez Et al.
Int J Neuropsychopharmacol 2018;21:938
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Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development.
Authors: Palmér Et al.
Sci Rep 2017;7:3191
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Pharmacological Chaperones of the DA Transporter Rescue DA Transporter Deficiency Syndrome Mutations in Heterologous Cells.
Authors: Beerepoot Et al.
J Biol Chem 2016;291:22053
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σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
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Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
PLoS One 2015;40:766
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Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.
Authors: Ribeiro Et al.
Neuropsychopharmacology 2014;23:2030
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DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1.
Authors: Soda Et al.
Mol Psychiatry 2013;18:898
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