Cytarabine

Catalog #: 4520
6 Citations Datasheet

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4520/50

Cytarabine | CAS No. 147-94-4 | DNA, RNA and Protein Synthesis Inhibitors

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Description: Nucleoside analog; inhibits DNA replication

Alternative Names: Cytosine b-D-arabinofuranoside

Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

Purity: ≥98%

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Product Details

Citations (6)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC₅₀ = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data

M.Wt:

243.22

Formula:

C₉H₁₃N₃O₅

Solubility:

Soluble to 100 mM in water and to 50 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

147-94-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacodynamics of cytar. alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial.
Sampath et al.
Blood., 2006;107:2517
Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytar. in metastatic and s.c. human tumor xenograft models.
Breistøl et al.
Cancer Res., 1999;59:2944
Effect of cytar. upon metabolism of phospholipids in leukemia L5178Y cells.
Yang et al.
Acta Pharmacol. Sin., 1986;7:368

Product Datasheets

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SDS

⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Cytarabine

The citations listed below are publications that use Tocris products. Selected citations for Cytarabine include:

6 Citations: Showing 1 - 6

Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.
Authors: Karen Et al.
Curr Protoc 2021;1:e141
The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG.
Authors: Uwe Et al.
Cancer Discov 2021;11:500-519
SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.
Authors: Oliver T Et al.
Commun Biol 2020;3:324
Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs.
Authors: Paul A Et al.
Autophagy 2019;15:900-907
Systematic analysis of protein turnover in primary cells.
Authors: Mathieson Et al.
Nat Commun 2018;9:689
Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression.
Authors: Bisikirska Et al.
Cancer Res 2016;76:664

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