CW 008
Chemical Name: 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
Purity: ≥98%
Biological Activity
CW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells.
Kim et al.
J.Cell.Physiol., 2013;228:617
Product Datasheets
Citations for CW 008
The citations listed below are publications that use Tocris products. Selected citations for CW 008 include:
4 Citations: Showing 1 - 4
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Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis.
Authors: Xun Et al.
Theranostics 2023;13:1247-1263
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Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins.
Authors: Karen E Et al.
Elife 2023;12
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A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells.
Authors: Yong Et al.
Toxicol Mech Methods 2021;31:393-399
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Bisphenol S enhances gap junction intercellular communication in ovarian theca cells.
Authors: Yong Et al.
Chemosphere 2021;263:128304
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