CVT 10216
Chemical Name: 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid
Purity: ≥98%
Biological Activity
CVT 10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A selective ALDH-2 inhibitor reduces anxiety in rats.
Overstreet et al.
Pharmacol.Biochem.Behav., 2009;94:255 -
Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of DA synthesis.
Yao et al.
Nat.Med., 2010;16:1024
Product Datasheets
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