CRT 0105950
Chemical Name: 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol
Purity: ≥98%
Biological Activity
CRT 0105950 is a potent LIMK1/2 inhibitor (IC50 values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties.
Charles et al.
J.Med.Chem., 2015;58:8309 -
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.
Mardilovich et al.
Oncotarget., 2015;6:38469
Product Datasheets
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