CORM 3

Catalog #: 5320 Datasheet

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CORM 3 | CAS No. 475473-26-8 | Miscellaneous Compounds

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Description: Water-soluble carbon monoxide-releasing molecule

Alternative Names: Carbon monoxide releasing molecule 3

Chemical Name: Tricarbonylchloro(glycinato)ruthenium

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CORM 3 is a water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.

Technical Data

M.Wt:

294.61

Formula:

C₅H₄ClNO₅Ru

Solubility:

Soluble to 100 mM in water

Storage:

Store at -20°C

CAS No:

475473-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.
Clark et al.
Circ.Res., 2003;93:e2
Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule.
Foresti et al.
Br.J.Pharmacol., 2004;142:453
Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages.
Sawle et al.
Br.J.Pharmacol., 2005;145:800
Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3.
Bani-Hani et al.
J.Pharmacol.Exp.Ther., 2006;318:1315
Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3).
Filippo et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2012;385:137

Product Datasheets

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