Compound E

Biological Activity

Compound E is a γ-secretase and notch patchway inhibitor. Compound E enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat. No. 1614), Compound E accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Compound E is active in vitro and in vivo.

For more information about how Compound E may be used, see our protocol: Generation of β cells from hPSCs

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors.
   Li et al.
   Proc.Natl.Acad.Sci.USA, 2011;108:8299
2. Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells.
   Ferrari-Toninelli et al.
   Neuro.Oncol., 2010;12:1231
3. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
   Beher et al.
   J.Biol.Chem., 2001;276:45394

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