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CMPD-1

Catalog #: 2186
3 Citations Datasheet
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2186/10
2186/50
CMPD-1 | CAS No. 41179-33-3 | p38 Inhibitors
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Description: Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

Technical Data

M.Wt:
349.4
Formula:
C22H20FNO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
41179-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.
    Gurgis et al.
    Cell Death Discovery, 2015;1:15028
  2. Discovery and characterisation of a substrate selective p38α inhibitor.
    Davidson et al.
    Biochemistry, 2004;43:11658

Product Datasheets

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Citations for CMPD-1

The citations listed below are publications that use Tocris products. Selected citations for CMPD-1 include:

3 Citations: Showing 1 - 3

  1. The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
    Authors: Ryals Et al.
    Front Cell Neurosci  2018;12:445
  2. p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly.
    Authors: Fricke Et al.
    J Virol  2013;87:1333
  3. EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis.
    Authors: Breindel Et al.
    Cancer Res  2013;73:5053

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